The largest-ever study of a million women has found that those who
smoke lose a decade of their lives, while kicking the smoking habit
before the age of 40 avoids more than 90 percent of the increased risk
of dying caused by continuing to smoke, while stopping before the age of
30 avoids over 97% of it.
The research has just been published in the online edition of the
British journal The Lancet, to mark the100th anniversary of the birth of
Sir Richard Doll, one of the first people to identify the link between
lung cancer and smoking.
A total of 1.3 million women were recruited to the study between 1996
and 2001, at ages 50 to 65 years. Participants completed a
questionnaire about lifestyle, medical and social factors and were
resurveyed by mail three years later. The National Health Service’s
central register notified the researchers when any participant died,
giving the cause of that death. Women were traced for an average of 12
years from the time they first joined; thus far, 66,000 study
participants died.
Initially, a fifth of the study participants were smokers, 28% were
ex-smokers and 52% had never smoked. Those who were still smokers at the
three-year follow-up survey were nearly three times as likely as
nonsmokers to die over the next nine years, even though some reduced
their risk by stopping smoking during this period.
This threefold death rate ratio means that two-thirds of all deaths
of smokers in their 50s, 60s, and 70s are caused by smoking, as most of
the difference between smokers and nonsmokers came from smoking-related
diseases such as lung cancer, chronic lung disease, heart disease, or
stroke. The risks among smokers increased steeply with the amount
smoked, although even for those who were light smokers at the start of
the study, mortality rates were double those for non-smokers.
The key finding is that both the hazards of smoking and,
correspondingly, the benefits of stopping are bigger than previous
studies have suggested; smokers who stopped around age 30 avoided 97% of
their excess risk of premature death, and although serious excess
hazards remained for decades among those who smoked until age 40 before
stopping, the excess hazards among those who continued smoking cheap Hilton cigs after age 40 were 10 times bigger.
According to University of Oxford co-author Prof. Richard Peto, who
was for many years a co-researcher with Doll on smoking epidemiology,
“If women smoke like men, they die like men – but, whether they are men
or women, smokers who stop before reaching middle age will on average
gain about an extra 10 years of life.” Peto added: “Both in the UK and
the US, women born around 1940 were the first generation in which many
smoked substantial numbers of discount cigarettes
throughout adult life. Hence, only in the 21st century could we observe
directly the full effects of prolonged smoking, and of prolonged
cessation, on premature mortality among women.”
Prof. Rachel Huxley of the University of Minnesota, in a published
comment, said: “That we had to wait until the 21st century to observe
the full consequences in women of a habit that was already widespread in
the mid- 20th century, when tobacco smoking pervaded much of the
developed world, might seem paradoxical. But this is because in most of
Europe and the US, the popularity of smoking among young women reached
its peak in the 1960s, decades later than for men. Hence, previous
studies have underestimated the full eventual impact of smoking on
mortality in women, simply because of the lengthy time lag between
smoking uptake by young women and disease onset in middle and old age.”
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